Buffalo Bills leading rusher James Cook was made inactive for Monday night’s game against the host New York Jets due to a toe injury.

Cook was limited at Saturday’s practice and deemed questionable for the game. He has 70 carries for 309 yards and four rushing touchdowns in five starts this season, along with 11 catches for 123 yards and a TD.

He did most of his damage Week 2 against the Miami Dolphins, gaining 95 yards from scrimmage and three touchdowns.

The Bills elevated Frank Gore Jr. from the practice squad and he is expected to see the first game action of his NFL career. He is the son of longtime running back Frank Gore, who played for both the Bills and the Jets late in his career.

Jets linebacker C.J. Mosley (toe), who hasn’t played since Week 2, is active.