Tyler Shough threw for 293 yards and two touchdowns to lead Louisville to a convincing 37-9 victory over visiting Pitt in their Atlantic Coast Conference matchup on Saturday.

Isaac Brown rushed for 93 yards and two scores on 13 carries for the Cardinals (7-4, 5-3 ACC), who racked up 505 yards.

Louisville dominated on both sides of the ball and led 34-0 just 62 seconds into the third quarter after Chris Bell’s 68-yard catch-and-run touchdown on a flat pass from Shough. Bell finished with 101 yards receiving on two catches.

The Panthers (7-4, 3-4) entered Saturday averaging nearly 429 yards a game, but the Cardinals allowed just 265 and forced three turnovers as Pittsburgh lost its fourth straight contest.

Pittsburgh took the opening kick and marched to the Louisville 7, only for Stanquan Clark to pick off Eli Holstein’s pass in the end zone for the first of his two interceptions on the night. Louisville converted that turnover into Brock Travelstead’s 41-yard field goal to take a 3-0 lead with 6:35 left in the first quarter.

Holstein started at quarterback for Pittsburgh after missing last week’s loss to Clemson due to a head injury. However, he left the game with 5:32 left in the opening quarter after being sacked by Ashton Gillotte at the Panthers 49.

As he was going down, Holstein’s left ankle rolled under Gillotte. He was already in a walking boot as he was carted off the field.

He was replaced by Nate Yarnell. After throwing for 350 yards against Clemson last week, Yarnell managed just 96 yards on 11-of-23 passing. He also threw an interception by Clark that led to Brown’s 15-yard scoring run.

David Lynch replaced Yarnell to start the fourth quarter.

Brown was in the starting lineup despite suffering a shoulder injury early last week at Stanford and continued producing at his prolific pace against the Panthers. He entered Saturday ranked second nationally averaging 7.4 yards a carry.